$1,248,000

beds

baths

1,630

square ft

643 Grand Avenue

South San Francisco, California 94080

New / MLS #82059314 / Single Family / South San Francisco

Listing information updated 8/30/2026 at 6:04pm

Ideally located near Downtown South San Francisco and the cities thriving biotech and life-sciences corridor, 643 Grand Avenue where space, comfort, and a remarkable garden setting come together in the heart of South San Francisco. 643 Grand Avenue offers a spacious and versatile layout with excellent access to major transportation and employment centers. The home features 3 bedrooms and 4 bathrooms, with a private full bathroom for each bedroom. Additional highlights include high ceilings, abundant natural light, hardwood floors, a full basement with ample storage, and a detached 2-car garage equipped with a 220-volt outlet for EV charging. The home also features a water purification system, tankless water heater, and water softener. The quaint lot includes a freshly manicured organic vegetable garden with sunflowers and offers potential for an ADU. Conveniently located near Downtown South San Francisco, Genentech, Caltrain, US-101, and I-280.

Full Features

Beds Above Grade:

Cooling System:

None

Heating System:

Central Forced Air

Appliances:

Water Softener

Main Level Primary Bedroom:

Fireplace:

Pool:

Age:

131 Years

Roof Type:

Shingle

Parking Type:

Detached, On Street

Parking Spaces:

Garage:

Garage - 2 Car(s)

Square Feet:

1,630

Lot Size:

3500 SquareFeet

Internal Features:

One Or More Skylights, Walkin Closet

Taxes & Assessments

Tax Amount:

N/A

Tax Year:

N/A

Location

Zip Code:

94080

City:

South San Francisco

County:

San Mateo

Schools

School District(s):

South San Francisco Unified

Elementary School:

N/A

Middle School:

N/A

High School:

N/A

Beds Above Grade:

Cooling System:

None

Heating System:

Central Forced Air

Appliances:

Water Softener

Main Level Primary Bedroom:

Fireplace:

Pool:

Age:

131 Years

Roof Type:

Shingle

Parking Type:

Detached, On Street

Parking Spaces:

Garage:

Garage - 2 Car(s)

Square Feet:

1,630

Lot Size:

3500 SquareFeet

Internal Features:

One Or More Skylights, Walkin Closet

Tax Amount:

N/A

Tax Year:

N/A

Zip Code:

94080

City:

South San Francisco

County:

San Mateo

School District(s):

South San Francisco Unified

Elementary School:

N/A

Middle School:

N/A

High School:

N/A

Listing Agent: Jill Penna

Listing Office: Christie's International Real Estate Sereno

Disclaimer: The data relating to real estate for sale on this display comes in part from the Internet Data Exchange program of the MLSListings MLS system. Real estate listings held by brokerage firms other than Christie’s International Real Estate Sereno are marked with the Internet Data Exchange icon (a stylized house inside a circle) and detailed information about them includes the names of the listing brokers and listing agents. Based on information from the MLSListings MLS as of 8/30/2026 at 6:04pm (date the MLS data was obtained). All data, including all measurements and calculations of area, is obtained from various sources and has not been, and will not be, verified by broker or MLS. All information should be independently reviewed and verified for accuracy.